There is no "WHY". This is how the debugger designed to do. It doesn't allow you to set breakpoints if the target is running when the option is enabled. But you can still set a breakpoint if the target is paused (stopped). LPMx.5 debug is quite useful if your system need to enter LPM3.5 or LPM4.5 and then wake-up later. In these two states, the clock and power to CPU is turned off. Since the CPU is off, how to debug CPU? This is what the option wants to solve.
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